View On-Demand Webinar: Bridging Species: IVIVE Approaches to Thyroid Hormone Clearance in Human & Rat Hepatocytes

Explore recent findings with Beas Bhattacharya, PhD, Global Regulatory Toxicologist at Corteva Agriscience, who will discuss the use of in vitro hepatocyte models to better understand liver-mediated thyroid disruption and improve human health risk assessment. This presentation highlights how new approach methodologies (NAMs) and quantitative in vitro to in vivo extrapolation (QIVIVE) can bridge data from mechanistic studies to biological outcomes, reducing reliance on animal testing. By comparing two hepatocyte models and correlating findings with short-term in vivo data, this work demonstrates how optimized in vitro systems can enable earlier detection of thyroid dysregulation and support next-generation risk assessment (NGRA) for safer chemical and drug development.

Key Takeaways:

• Understand species-specific differences in thyroid hormone clearance.
• Learn how NAM-based hepatocyte models inform NGRA.
• Explore how QIVIVE supports mechanistic linkage between in vitro data and in vivo outcomes.

See how these tools can derisk discovery molecules and refine thyroid toxicity prediction.

Guest Speaker: Beas Bhattacharya, PhD, Global Regulatory Toxicologist, Corteva Agriscience

Speaker Bio:

Beas Bhattacharya earned her bachelor’s degree in Electronics and Communication Engineering in India before pursuing her passion for biological sciences. She completed her Ph.D. in Toxicology at Indiana University Bloomington, where her research focused on understanding the effects of vaping liquids on zebrafish embryonic development. Following her doctoral work, Beas joined Corteva Agriscience as a Postdoctoral Research Fellow, investigating thyroid toxicity using zebrafish and TruVivo hepatocyte models. Currently, Beas serves as a Global Regulatory Toxicologist at Corteva, where she supports the registration of products worldwide across both seeds and crop protection portfolios. Her role involves ensuring compliance with global regulatory standards and contributing to the safe and sustainable use of agricultural solutions.

Outside of work, Beas enjoys gardening, collecting books and caring for her four rescued pets. She is also deeply committed to social impact and actively leads Corteva’s global initiatives that empower and support indigenous communities.